KMID : 1161420220250030230
|
|
Journal of Medicinal Food 2022 Volume.25 No. 3 p.230 ~ p.238
|
|
¥â-Glucan-Rich Extract of Gray Oyster Mushroom, Pleurotus pulmonarius, Improves Object Recognition Memory and Hippocampus Morphology in Mice Fed a High-Fat Diet
|
|
Tarmizi Nor Athirah Kamaliah Ahmad
Kushairi Naufal Phan Chia Wei Sabaratnam Vikineswary Naidu Murali David Pamela
|
|
Abstract
|
|
|
Obesity may cause behavioral alterations, while maternal obesity can contribute to metabolic disorders in subsequent generations. The effect of ¥â-glucan-rich Pleurotus pulmonarius (¥âgPp) was investigated on mouse neurobehavior and hippocampus and its offspring's hippocampus development. Female ICR mice were fed with normal diet (ND), ND with ¥âgPp, high-fat diet (HFD), or HFD with ¥âgPp for 3 months followed by behavioral test and mating. Immunohistochemistry for the expression of neuronal nuclear protein (NeuN) and ionized calcium binding adaptor molecule-1 (Iba-1) in the hippocampus was carried out. ¥âgPp significantly enhanced short-term object recognition memory in HFD-fed mice. ¥âgPp also ameliorated the histological alterations and neuronal loss and increased Iba-1-positive microglia in the hippocampus regions of HFD-fed mice and their male offspring. These findings demonstrated that ¥âgPp supplementation attenuated the effects of HFD on object recognition memory and the alterations on the hippocampal regions of maternal mice and their male offspring.
|
|
KEYWORD
|
|
inflammation, microglia, neuron, neuroprotective, obesity, offspring
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|